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In this trial, 77.1 per cent of those on semaglutide lost 5 per cent or more of their body weight after two years, versus 34.4 per cent in the placebo group

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This plan may include: Tapering Off Semaglutide : Gradually reducing the dosage of Semaglutide to minimize withdrawal symptoms

Concurrently, novel investigations are exploring targeted microbial therapies, including probiotics, prebiotics, and fecal microbiota transplantation (FMT), to optimize therapeutic outcomes for PCOS patients ( Figure 4 , Table 2 )